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Mathematical Approach to Differentiate Spontaneous and Induced Evolution to Drug Resistance During Cancer Treatment

PURPOSE: Drug resistance is a major impediment to the success of cancer treatment. Resistance is typically thought to arise from random genetic mutations, after which mutated cells expand via Darwinian selection. However, recent experimental evidence suggests that progression to drug resistance need...

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Bibliographische Detailangaben
Veröffentlicht in:JCO Clin Cancer Inform
Hauptverfasser: Greene, James M., Gevertz, Jana L., Sontag, Eduardo D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Clinical Oncology 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6873992/
https://ncbi.nlm.nih.gov/pubmed/30969799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/CCI.18.00087
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