CRISPRa-mediated FOXP3 gene upregulation in mammalian cells

BACKGROUND: Forkhead box P3(+) (FOXP3(+)) regulatory T cells (Tregs) are a subset of lymphocytes, critical for the maintenance of immune homeostasis. Loss-of-function mutations of the FOXP3 gene in animal models and humans results in loss of differentiation potential into Treg cells and are responsi...

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發表在:Cell Biosci
Main Authors: Forstnerič, Vida, Oven, Irena, Ogorevc, Jernej, Lainšček, Duško, Praznik, Arne, Lebar, Tina, Jerala, Roman, Horvat, Simon
格式: Artigo
語言:Inglês
出版: BioMed Central 2019
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6873431/
https://ncbi.nlm.nih.gov/pubmed/31832140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-019-0357-0
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