Heparin potentiates Avastin-mediated inhibition of VEGF binding to fibronectin and rescues Avastin activity at acidic pH

Vascular endothelial growth factor-A (VEGF) plays a critical role in stimulating angiogenesis in normal and disease states. Anti-VEGF antibodies have been developed to manage pathological angiogenesis. Bevacizumab, sold under the brand name Avastin, is a humanized mAb that binds VEGF and blocks its...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Tsiros, Divyabharathy, Sheehy, Casey E., Pecchia, Surenna, Nugent, Matthew A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Glycobiology and Extracellular Matrices
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6873198/
https://ncbi.nlm.nih.gov/pubmed/31601651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009194
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