Off-Target Effects in Transgenic Mice: Characterization of Dopamine Transporter (DAT)-Cre Transgenic Mouse Lines Exposes Multiple Non-Dopaminergic Neuronal Clusters Available for Selective Targeting within Limbic Neurocircuitry

Transgenic mouse lines are instrumental in our attempt to understand brain function. Promoters driving transgenic expression of the gene encoding Cre recombinase are crucial to ensure selectivity in Cre-mediated targeting of floxed alleles using the Cre-Lox system. For the study of dopamine (DA) neu...

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Bibliographische Detailangaben
Veröffentlicht in:eNeuro
Hauptverfasser: Papathanou, Maria, Dumas, Sylvie, Pettersson, Hanna, Olson, Lars, Wallén-Mackenzie, Åsa
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2019
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New Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6873162/
https://ncbi.nlm.nih.gov/pubmed/31481399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0198-19.2019
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