MUC1-C REPRESSES THE RASSF1A TUMOR SUPPRESSOR IN HUMAN CARCINOMA CELLS

RASSF1A encodes a tumor suppressor that inhibits the RAS→RAF→MEK→ERK pathway and is one of the most frequently inactivated genes in human cancers. MUC1-C is an oncogenic effector of the cancer cell epigenome that is overexpressed in diverse carcinomas. We show here that MUC1-C represses RASSF1A expr...

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Bibliografske podrobnosti
izdano v:Oncogene
Main Authors: Rajabi, Hasan, Hata, Tsuyoshi, Li, Wei, Long, Mark D, Hu, Qiang, Liu, Song, Raina, Deepak, Kui, Ling, Hong, Deli, Samur, Mehmet, Kufe, Donald
Format: Artigo
Jezik:Inglês
Izdano: 2019
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6872931/
https://ncbi.nlm.nih.gov/pubmed/31435022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0940-1
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