Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Inflammation and Restored by Empagliflozin

The positive findings of the EMPA-REG OUTCOME trial (Randomized, Placebo-Controlled Cardiovascular Outcome Trial of Empagliflozin) on heart failure (HF) outcome in patients with type 2 diabetes mellitus suggest a direct effect of empagliflozin on the heart. These patients frequently have HF with pre...

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Detalhes bibliográficos
Publicado no:JACC Basic Transl Sci
Main Authors: Juni, Rio P., Kuster, Diederik W.D., Goebel, Max, Helmes, Michiel, Musters, René J.P., van der Velden, Jolanda, Koolwijk, Pieter, Paulus, Walter J., van Hinsbergh, Victor W.M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
PRECLINICAL RESEARCH
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6872802/
https://ncbi.nlm.nih.gov/pubmed/31768475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2019.04.003
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