End‐diastolic force pre‐activates cardiomyocytes and determines contractile force: role of titin and calcium

Titin functions as a molecular spring, and cardiomyocytes are able, through splicing, to control the length of titin. We hypothesized that together with diastolic [Ca(2+)], titin‐based stretch pre‐activates cardiomyocytes during diastole and is a major determinant of force production in the subseque...

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Najafi, Aref, van de Locht, Martijn, Schuldt, Maike, Schönleitner, Patrick, van Willigenburg, Menne, Bollen, Ilse, Goebel, Max, Ottenheijm, Coen A. C., van der Velden, Jolanda, Helmes, Michiel, Kuster, Diederik W. D.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Cardiovascular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6852589/
https://ncbi.nlm.nih.gov/pubmed/31314138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP277985
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