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Splice-site variant in ACSL5: a marker promoting opposing effect on cell viability and protein expression

Long-chain Acyl-CoA synthetases (ACSLs) activate fatty acids (FAs) by thioesterification with Coenzyme A (CoA), generating FA-CoAs. These products are essential for lipid metabolism and carcinogenesis. In previous study, we identified an intronic variant rs2256368:A>G, whose G allele promotes exo...

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Foilsithe in:Eur J Hum Genet
Main Authors: Pérez-Núñez, Iván, Karaky, Mohamad, Fedetz, María, Barrionuevo, Cristina, Izquierdo, Guillermo, Matesanz, Fuencisla, Alcina, Antonio
Formáid: Artigo
Teanga:Inglês
Foilsithe: Springer International Publishing 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6871522/
https://ncbi.nlm.nih.gov/pubmed/31053784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41431-019-0414-5
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