Crowding-Induced Elongated Conformation of Urea-Unfolded Apoazurin: Investigating the Role of Crowder Shape in Silico

Here, we show by solution nuclear magnetic resonance measurements that the urea-unfolded protein apoazurin becomes elongated when the synthetic crowding agent dextran 20 is present, in contrast to the prediction from the macromolecular crowding effect based on the argument of volume exclusion. To ex...

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Bibliografiske detaljer
Udgivet i:J Phys Chem B
Main Authors: Zegarra, Fabio C., Homouz, Dirar, Gasic, Andrei G., Babel, Lucas, Kovermann, Michael, Wittung-Stafshede, Pernilla, Cheung, Margaret S.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6868533/
https://ncbi.nlm.nih.gov/pubmed/30963769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.9b00782
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