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R-Loops Promote Antisense Transcription across the Mammalian Genome

Widespread antisense long noncoding RNA (lncRNA) overlap with many protein-coding genes in mammals and emanate from gene promoter, enhancer, and termination regions. However, their origin and biological purpose remain unclear. We show that these antisense lncRNA can be generated by R-loops that form...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Tan-Wong, Sue Mei, Dhir, Somdutta, Proudfoot, Nick J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6868509/
https://ncbi.nlm.nih.gov/pubmed/31679819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.10.002
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