Branch site bulge conformations in domain 6 determine functional sugar puckers in group II intron splicing

Although group II intron ribozymes are intensively studied the question how structural dynamics affects splicing catalysis has remained elusive. We report for the first time that the group II intron domain 6 exists in a secondary structure equilibrium between a single- and a two-nucleotide bulge con...

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Bibliografische gegevens
Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Plangger, Raphael, Juen, Michael Andreas, Hoernes, Thomas Philipp, Nußbaumer, Felix, Kremser, Johannes, Strebitzer, Elisabeth, Klingler, David, Erharter, Kevin, Tollinger, Martin, Erlacher, Matthias David, Kreutz, Christoph
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2019
Onderwerpen:
Structural Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6868427/
https://ncbi.nlm.nih.gov/pubmed/31665419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz965
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