Branch site bulge conformations in domain 6 determine functional sugar puckers in group II intron splicing

Although group II intron ribozymes are intensively studied the question how structural dynamics affects splicing catalysis has remained elusive. We report for the first time that the group II intron domain 6 exists in a secondary structure equilibrium between a single- and a two-nucleotide bulge con...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Plangger, Raphael, Juen, Michael Andreas, Hoernes, Thomas Philipp, Nußbaumer, Felix, Kremser, Johannes, Strebitzer, Elisabeth, Klingler, David, Erharter, Kevin, Tollinger, Martin, Erlacher, Matthias David, Kreutz, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6868427/
https://ncbi.nlm.nih.gov/pubmed/31665419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz965
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