HER3-targeted protein chimera forms endosomolytic capsomeres and self-assembles into stealth nucleocapsids for systemic tumor homing of RNA interference in vivo

RNA interference represents a potent intervention for cancer treatment but requires a robust delivery agent for transporting gene-modulating molecules, such as small interfering RNAs (siRNAs). Although numerous molecular approaches for siRNA delivery are adequate in vitro, delivery to therapeutic ta...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Alonso-Valenteen, Felix, Pacheco, Sayuri, Srinivas, Dustin, Rentsendorj, Altan, Chu, David, Lubow, Jay, Sims, Jessica, Miao, Tianxin, Mikhael, Simoun, Hwang, Jae Youn, Abrol, Ravinder, Medina Kauwe, Lali K
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Chemical Biology and Nucleic Acid Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6868389/
https://ncbi.nlm.nih.gov/pubmed/31617560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz900
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