A novel mode of DnaA–DnaA interaction promotes ADP dissociation for reactivation of replication initiation activity

ATP-DnaA is temporally increased to initiate replication during the cell cycle. Two chromosomal loci, DARS (DnaA-reactivating sequences) 1 and 2, promote ATP-DnaA production by nucleotide exchange of ADP-DnaA for timely initiation. ADP-DnaA complexes are constructed on DARS1 and DARS2, bearing a clu...

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Bibliografski detalji
Izdano u:Nucleic Acids Res
Glavni autori: Sugiyama, Ryo, Kasho, Kazutoshi, Miyoshi, Kenya, Ozaki, Shogo, Kagawa, Wataru, Kurumizaka, Hitoshi, Katayama, Tsutomu
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Genome Integrity, Repair and Replication
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6868365/
https://ncbi.nlm.nih.gov/pubmed/31535134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz795
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