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Thermodynamic analysis of multivalent binding of functionalized nanoparticles to membrane surface reveals the importance of membrane entropy and nanoparticle entropy in adhesion of flexible nanoparticles

We present a quantitative model for multivalent binding of ligand-coated flexible polymeric nanoparticles (NPs) to a flexible membrane expressing receptors. The model is developed using a multiscale computational framework by coupling a continuum field model for the cell membrane with a coarse-grain...

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Vydáno v:Soft Matter
Hlavní autoři: Farokhirad, Samaneh, Bradley, Ryan P., Radhakrishnan, Ravi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6868310/
https://ncbi.nlm.nih.gov/pubmed/31670338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sm01653h
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