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Brain-targeted enzyme-loaded nanoparticles: A breach through the blood-brain barrier for enzyme replacement therapy in Krabbe disease

Lysosomal storage disorders (LSDs) result from an enzyme deficiency within lysosomes. The systemic administration of the missing enzyme, however, is not effective in the case of LSDs with central nervous system (CNS)-involvement. Here, an enzyme delivery system based on the encapsulation of cross-li...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Sci Adv
मुख्य लेखकों: Del Grosso, Ambra, Galliani, Marianna, Angella, Lucia, Santi, Melissa, Tonazzini, Ilaria, Parlanti, Gabriele, Signore, Giovanni, Cecchini, Marco
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Association for the Advancement of Science 2019
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6867879/
https://ncbi.nlm.nih.gov/pubmed/31799395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax7462
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