Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease

Krabbe disease (KD) is a neurodegenerative disorder caused by the lack of β- galactosylceramidase enzymatic activity and by widespread accumulation of the cytotoxic galactosyl-sphingosine in neuronal, myelinating and endothelial cells. Despite the wide use of Twitcher mice as experimental model for...

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Udgivet i:Sci Rep
Main Authors: Cappello, Valentina, Marchetti, Laura, Parlanti, Paola, Landi, Silvia, Tonazzini, Ilaria, Cecchini, Marco, Piazza, Vincenzo, Gemmi, Mauro
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5431369/
https://ncbi.nlm.nih.gov/pubmed/28442746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-016-0001-8
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