Nucleophilic Arylation of Halopurines Facilitated by Brønsted Acid in Fluoroalcohol

Various aryl-substituted purine derivatives were synthesized through the direct arylation of halopurines with aromatic compounds, facilitated by the combination of triflic acid and fluoroalcohol. This metal-free method is complementary to conventional coupling reactions using metal catalysts and rea...

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Publicat a:Molecules
Autors principals: Takenaga, Naoko, Shoji, Toshitaka, Menjo, Takayuki, Hirai, Akiko, Ueda, Shohei, Kikushima, Kotaro, Hanasaki, Tomonori, Dohi, Toshifumi
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
Matèries:
Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6865213/
https://ncbi.nlm.nih.gov/pubmed/31652675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24213812
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