Multimerization through Pegylation Improves Pharmacokinetic Properties of scFv Fragments of GD2-Specific Antibodies

Antigen-binding fragments of antibodies specific to the tumor-associated ganglioside GD2 are well poised to play a substantial role in modern GD2-targeted cancer therapies, however, rapid elimination from the body and reduced affinity compared to full-length antibodies limit their therapeutic potent...

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Publicado en:Molecules
Autores principales: V. Kholodenko, Irina, V. Kalinovsky, Daniel, V. Svirshchevskaya, Elena, I. Doronin, Igor, V. Konovalova, Maria, V. Kibardin, Alexey, V. Shamanskaya, Tatyana, S. Larin, Sergey, M. Deyev, Sergey, V. Kholodenko, Roman
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6864547/
https://ncbi.nlm.nih.gov/pubmed/31653037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24213835
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