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De-Novo-Designed Translation-Repressing Riboregulators for Multi-Input Cellular Logic

Efforts to construct synthetic biological circuits with more complex functions have often been hindered by the idiosyncratic behavior, limited dynamic range, and crosstalk of commonly utilized parts. Here, we employ de novo RNA design to develop two high-performance translational repressors with sen...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Kim, Jongmin, Zhou, Yu, Carlson, Paul D., Teichmann, Mario, Chaudhary, Soma, Simmel, Friedrich C., Silver, Pamela A., Collins, James J., Lucks, Julius B., Yin, Peng, Green, Alexander A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6864284/
https://ncbi.nlm.nih.gov/pubmed/31686032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0388-1
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