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De-Novo-Designed Translation-Repressing Riboregulators for Multi-Input Cellular Logic

Efforts to construct synthetic biological circuits with more complex functions have often been hindered by the idiosyncratic behavior, limited dynamic range, and crosstalk of commonly utilized parts. Here, we employ de novo RNA design to develop two high-performance translational repressors with sen...

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Publicado en:Nat Chem Biol
Autores principales: Kim, Jongmin, Zhou, Yu, Carlson, Paul D., Teichmann, Mario, Chaudhary, Soma, Simmel, Friedrich C., Silver, Pamela A., Collins, James J., Lucks, Julius B., Yin, Peng, Green, Alexander A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6864284/
https://ncbi.nlm.nih.gov/pubmed/31686032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0388-1
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