STAT3-induced Wnt5a provides chronic lymphocytic leukemia cells with survival advantage

The wingless and integration site growth factor-5a (Wnt5a) is a ligand of the receptor tyrosine kinase-like orphan receptor-1 (ROR1). Since both Wnt5a and ROR1 are expressed in circulating chronic lymphocytic leukemia (CLL) cells and because in other cell types STAT3, which is constitutively activat...

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Udgivet i:J Immunol
Main Authors: Rozovski, Uri, Harris, David M., Li, Ping, Liu, Zhiming, Jain, Preetesh, Ferrajoli, Alessandra, Burger, Jan A., Bose, Prithviraj, Thompson, Phillip A., Jain, Nitin, Wierda, William G., Uziel, Orit, Keating, Michael J., Estrov, Zeev
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6864283/
https://ncbi.nlm.nih.gov/pubmed/31645416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900389
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