IL-25 exacerbates autoimmune aortitis in IL-1 receptor antagonist-deficient mice

IL-25, a member of the IL-17 family of cytokines, is known to enhance type 2 immune responses, but suppress type 3 (IL-17A)-mediated immune responses. Mice deficient in IL-1 receptor antagonist (Il1rn(−/−) mice) have excessive IL-1 signaling, resulting in spontaneous development of IL-1–, TNF– and I...

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Publicado no:Sci Rep
Main Authors: Yoshizaki, Takamichi, Itoh, Satoshi, Yamaguchi, Sachiko, Numata, Takafumi, Nambu, Aya, Kimura, Naoyuki, Suto, Hajime, Okumura, Ko, Sudo, Katsuko, Yamaguchi, Atsushi, Nakae, Susumu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6864066/
https://ncbi.nlm.nih.gov/pubmed/31745167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-53633-0
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