Functional and structural basis of E. coli enolase inhibition by SF2312: a mimic of the carbanion intermediate

Many years ago, the natural secondary metabolite SF2312, produced by the actinomycete Micromonospora, was reported to display broad spectrum antibacterial properties against both Gram-positive and Gram-negative bacteria. Recent studies have revealed that SF2312, a natural phosphonic acid, functions...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Krucinska, Jolanta, Lombardo, Michael N., Erlandsen, Heidi, Hazeen, Akram, Duay, Searle S., Pattis, Jason G., Robinson, Victoria L., May, Eric R., Wright, Dennis L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863902/
https://ncbi.nlm.nih.gov/pubmed/31745118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-53301-3
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