Selection of an optimal macrocyclic chelator improves the imaging of prostate cancer using cobalt-labeled GRPR antagonist RM26

Gastrin-releasing peptide receptors (GRPRs) are promising targets in oligometastatic prostate cancer. We have recently used (55)Co (T(1/2 = )17.5 h) as a label for next day PET imaging of GRPR expression obtaining high imaging contrast. The radionuclide-chelator combination can significantly influen...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Mitran, Bogdan, Thisgaard, Helge, Rinne, Sara, Dam, Johan Hygum, Azami, Frishta, Tolmachev, Vladimir, Orlova, Anna, Rosenström, Ulrika
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863848/
https://ncbi.nlm.nih.gov/pubmed/31745219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52914-y
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