CYRI (FAM49) proteins are local inhibitors of Scar/WAVE induced lamellipodia that bind directly to active Rac1

Actin-based protrusions driving cell migration are reinforced through positive feedback, but it is unclear how the cell restricts the eventual size of protrusions or limits positive signals to allow them to split or retract. We have identified an evolutionarily conserved regulator of the protrusion...

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Gepubliceerd in:Nat Cell Biol
Hoofdauteurs: Fort, Loic, Batista, Jose, Thomason, Peter A., Spence, Heather J., Whitelaw, Jamie A., Tweedy, Luke, Greaves, Jennifer, Martin, Kirsty J., Anderson, Kurt I., Brown, Peter, Lilla, Sergio, Neilson, Matthew P., Tafelmeyer, Petra, Zanivan, Sara, Ismail, Shehab, Bryant, David M., Tomkinson, Nicholas C.O., Chamberlain, Luke H., Mastick, Grant S., Insall, Robert H., Machesky, Laura M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863750/
https://ncbi.nlm.nih.gov/pubmed/30250061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-018-0198-9
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