Hypothalamic miR-30 regulates puberty onset via repression of the puberty-suppressing factor, Mkrn3

Mkrn3, the maternally imprinted gene encoding the makorin RING-finger protein-3, has recently emerged as putative pubertal repressor, as evidenced by central precocity caused by MKRN3 mutations in humans; yet, the molecular underpinnings of this key regulatory action remain largely unexplored. We re...

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Publicado no:PLoS Biol
Main Authors: Heras, Violeta, Sangiao-Alvarellos, Susana, Manfredi-Lozano, Maria, Sanchez-Tapia, María J., Ruiz-Pino, Francisco, Roa, Juan, Lara-Chica, Maribel, Morrugares-Carmona, Rosario, Jouy, Nathalie, Abreu, Ana P., Prevot, Vincent, Belsham, Denise, Vazquez, Maria J., Calzado, Marco A., Pinilla, Leonor, Gaytan, Francisco, Latronico, Ana C., Kaiser, Ursula B., Castellano, Juan M., Tena-Sempere, Manuel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863565/
https://ncbi.nlm.nih.gov/pubmed/31697675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000532
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