Development and validation of LC-MS/MS method for imatinib and norimatinib monitoring by finger-prick DBS in gastrointestinal stromal tumor patients

The introduction of imatinib, an oral tyrosine kinase inhibitor, as first-line standard therapy in patients with unresectable, metastatic, or recurrent gastro-intestinal stromal tumor (GIST), strongly improved their treatment outcomes. However, therapeutic drug monitoring (TDM) is recommended for th...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Iacuzzi, Valentina, Posocco, Bianca, Zanchetta, Martina, Montico, Marcella, Marangon, Elena, Poetto, Ariana Soledad, Buzzo, Mauro, Gagno, Sara, Buonadonna, Angela, Guardascione, Michela, Casetta, Bruno, Toffoli, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863526/
https://ncbi.nlm.nih.gov/pubmed/31743371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0225225
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