Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome

Myeloid leukemia in Down syndrome (ML-DS) clonally evolves from transient abnormal myelopoiesis (TAM), a preleukemic condition in DS newborns. To define mechanisms of leukemic transformation, we combined exome and targeted resequencing of 111 TAM and 141 ML-DS samples with functional analyses. TAM r...

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Publicat a:Cancer Cell
Autors principals: Labuhn, Maurice, Perkins, Kelly, Matzk, Sören, Varghese, Leila, Garnett, Catherine, Papaemmanuil, Elli, Metzner, Marlen, Kennedy, Alison, Amstislavskiy, Vyacheslav, Risch, Thomas, Bhayadia, Raj, Samulowski, David, Hernandez, David Cruz, Stoilova, Bilyana, Iotchkova, Valentina, Oppermann, Udo, Scheer, Carina, Yoshida, Kenichi, Schwarzer, Adrian, Taub, Jeffrey W., Crispino, John D., Weiss, Mitchell J., Hayashi, Yasuhide, Taga, Takashi, Ito, Etsuro, Ogawa, Seishi, Reinhardt, Dirk, Yaspo, Marie-Laure, Campbell, Peter J., Roberts, Irene, Constantinescu, Stefan N., Vyas, Paresh, Heckl, Dirk, Klusmann, Jan-Henning
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863161/
https://ncbi.nlm.nih.gov/pubmed/31303423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.06.007
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