Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome

Myeloid leukemia in Down syndrome (ML-DS) clonally evolves from transient abnormal myelopoiesis (TAM), a preleukemic condition in DS newborns. To define mechanisms of leukemic transformation, we combined exome and targeted resequencing of 111 TAM and 141 ML-DS samples with functional analyses. TAM r...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Labuhn, Maurice, Perkins, Kelly, Matzk, Sören, Varghese, Leila, Garnett, Catherine, Papaemmanuil, Elli, Metzner, Marlen, Kennedy, Alison, Amstislavskiy, Vyacheslav, Risch, Thomas, Bhayadia, Raj, Samulowski, David, Hernandez, David Cruz, Stoilova, Bilyana, Iotchkova, Valentina, Oppermann, Udo, Scheer, Carina, Yoshida, Kenichi, Schwarzer, Adrian, Taub, Jeffrey W., Crispino, John D., Weiss, Mitchell J., Hayashi, Yasuhide, Taga, Takashi, Ito, Etsuro, Ogawa, Seishi, Reinhardt, Dirk, Yaspo, Marie-Laure, Campbell, Peter J., Roberts, Irene, Constantinescu, Stefan N., Vyas, Paresh, Heckl, Dirk, Klusmann, Jan-Henning
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863161/
https://ncbi.nlm.nih.gov/pubmed/31303423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.06.007
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados