Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate

BACKGROUND: With ever-increasing exposure to engineered nanomaterials (NMs), there is an urgent need to evaluate the probability of consequential adverse effects. The potential for NM translocation to distal organs is a realistic prospect, with the liver being one of the most important target organs...

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Bibliographic Details
Published in:Part Fibre Toxicol
Main Authors: Kermanizadeh, Ali, Berthing, Trine, Guzniczak, Ewa, Wheeldon, Melanie, Whyte, Graeme, Vogel, Ulla, Moritz, Wolfgang, Stone, Vicki
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6862829/
https://ncbi.nlm.nih.gov/pubmed/31739797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12989-019-0326-0
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