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The oncogene Gankyrin is expressed in testicular cancer and contributes to cisplatin sensitivity in embryonal carcinoma cells

BACKGROUND: Testicular germ cell cancer (TGCC) develops from pre-malignant germ neoplasia in situ (GCNIS) cells. GCNIS originates from fetal gonocytes (POU5F1(+)/MAGE-A4(−)), which fail to differentiate to pre-spermatogonia (POU5F1(−)/MAGE-A4(+)) and undergo malignant transformation. Gankyrin is an...

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Detalles Bibliográficos
Publicado en:BMC Cancer
Autores principales: Camacho-Moll, Maria E., Macdonald, Joni, Looijenga, L. H. J., Rimmer, Michael P., Donat, Roland, Marwick, John A., Shukla, C. J., Carragher, Neil, Jørgensen, Anne, Mitchell, Rod T.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6862764/
https://ncbi.nlm.nih.gov/pubmed/31744479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-6340-7
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