Synthesis and Immunological Evaluation of Disaccharide Bearing MUC-1 Glycopeptide Conjugates with Virus-like Particles

Mucin-1 (MUC1) is a highly attractive antigenic target for anticancer vaccines. Naturally existing MUC1 can contain multiple types of O-linked glycans, including the Thomsen–Friedenreich (Tf) antigen and the Sialyl Thomsen-nouveau (STn) antigen. In order to target these antigens as potential antican...

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Pubblicato in:ACS Chem Biol
Autori principali: Wu, Xuanjun, McKay, Craig, Pett, Christian, Yu, Jin, Schorlemer, Manuel, Ramadan, Sherif, Lang, Shuyao, Behren, Sandra, Westerlind, Ulrika, Finn, M. G., Huang, Xuefei
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6862716/
https://ncbi.nlm.nih.gov/pubmed/31498587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00381
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