microRNA-mediated GAS1 downregulation promotes the proliferation of synovial fibroblasts by PI3K-Akt signaling in osteoarthritis

Hyperplastic synovial fibroblasts (SFs) serve a critical role in the pathogenesis of knee osteoarthritis (OA); however, the molecular mechanism involved in OA during synovial tissue hyperproliferation remains unclear. Growth arrest-specific gene 1 (GAS1), a cell growth repressor gene, was found to b...

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Publicat a:Exp Ther Med
Autors principals: Dong, Chuan, Wang, Xinli, Li, Nan, Zhang, Kailiang, Wang, Xiaoyan, Zhang, Haomeng, Wang, Haipeng, Wang, Bo, An, Ming, Ma, Baoan
Format: Artigo
Idioma:Inglês
Publicat: D.A. Spandidos 2019
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6862556/
https://ncbi.nlm.nih.gov/pubmed/31777535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2019.8101
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