INCB050465 (Parsaclisib), a Novel Next-Generation Inhibitor of Phosphoinositide 3-Kinase Delta (PI3Kδ)

[Image: see text] A medicinal chemistry effort focused on identifying a structurally diverse candidate for phosphoinositide 3-kinase delta (PI3Kδ) led to the discovery of clinical candidate INCB050465 (20, parsaclisib). The unique structure of 20 contains a pyrazolopyrimidine hinge-binder in place o...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Yue, Eddy W., Li, Yun-Long, Douty, Brent, He, Chunhong, Mei, Song, Wayland, Brian, Maduskuie, Thomas, Falahatpisheh, Nikoo, Sparks, Richard B., Polam, Padmaja, Zhu, Wenyu, Glenn, Joseph, Feng, Hao, Zhang, Ke, Li, Yanlong, He, Xin, Katiyar, Kamna, Covington, Maryanne, Feldman, Patricia, Shin, Niu, Wang, Kathy He, Diamond, Sharon, Li, Yu, Koblish, Holly K., Hall, Leslie, Scherle, Peggy, Yeleswaram, Swamy, Xue, Chu-Biao, Metcalf, Brian, Combs, Andrew P., Yao, Wenqing
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2019
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6862339/
https://ncbi.nlm.nih.gov/pubmed/31749910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00334
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