Characterization of human cancer xenografts in humanized mice

per Rios-Doria, Jonathan, Stevens, Christina, Maddage, Christopher, Lasky, Kerri, Koblish, Holly K
Publicat a J Immunother Cancer (2020)

Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor mi...

per Spranger, Stefani, Koblish, Holly K, Horton, Brendan, Scherle, Peggy A, Newton, Robert, Gajewski, Thomas F
Publicat 2014

The pan-PIM inhibitor INCB053914 displays potent synergy in combination with ruxolitinib in models of MPN

per Mazzacurati, Lucia, Collins, Robert J., Pandey, Garima, Lambert-Showers, Que T., Amin, Narmin E., Zhang, Ling, Stubbs, Matthew C., Epling-Burnette, Pearlie K., Koblish, Holly K., Reuther, Gary W.
Publicat a Blood Adv (2019)

INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology

per Yue, Eddy W., Sparks, Richard, Polam, Padmaja, Modi, Dilip, Douty, Brent, Wayland, Brian, Glass, Brian, Takvorian, Amy, Glenn, Joseph, Zhu, Wenyu, Bower, Michael, Liu, Xiangdong, Leffet, Lynn, Wang, Qian, Bowman, Kevin J., Hansbury, Michael J., Wei, Min, Li, Yanlong, Wynn, Richard, Burn, Timothy C., Koblish, Holly K., Fridman, Jordan S., Emm, Tom, Scherle, Peggy A., Metcalf, Brian, Combs, Andrew P.
Publicat a ACS Med Chem Lett (2017)

INCB050465 (Parsaclisib), a Novel Next-Generation Inhibitor of Phosphoinositide 3-Kinase Delta (PI3Kδ)

per Yue, Eddy W., Li, Yun-Long, Douty, Brent, He, Chunhong, Mei, Song, Wayland, Brian, Maduskuie, Thomas, Falahatpisheh, Nikoo, Sparks, Richard B., Polam, Padmaja, Zhu, Wenyu, Glenn, Joseph, Feng, Hao, Zhang, Ke, Li, Yanlong, He, Xin, Katiyar, Kamna, Covington, Maryanne, Feldman, Patricia, Shin, Niu, Wang, Kathy He, Diamond, Sharon, Li, Yu, Koblish, Holly K., Hall, Leslie, Scherle, Peggy, Yeleswaram, Swamy, Xue, Chu-Biao, Metcalf, Brian, Combs, Andrew P., Yao, Wenqing
Publicat a ACS Med Chem Lett (2019)