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Evidence for Nanoparticle-Induced Lysosomal Dysfunction in Lung Adenocarcinoma (A549) Cells

Background: Polystyrene nanoparticles (PNP) are taken up by primary rat alveolar epithelial cell monolayers (RAECM) in a time-, dose-, and size-dependent manner without involving endocytosis. Internalized PNP in RAECM activate autophagy, are delivered to lysosomes, and undergo [Ca(2+)]-dependent exo...

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Publicat a:Int J Mol Sci
Autors principals: Sipos, Arnold, Kim, Kwang-Jin, Sioutas, Constantinos, Crandall, Edward D.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6861930/
https://ncbi.nlm.nih.gov/pubmed/31652767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20215253
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