In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury—Lessons Learned

We developed a pipeline for the discovery of transcriptomics-derived disease-modifying therapies and used it to validate treatments in vitro and in vivo that could be repurposed for TBI treatment. Desmethylclomipramine, ionomycin, sirolimus and trimipramine, identified by in silico LINCS analysis as...

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Gepubliceerd in:Int J Mol Sci
Hoofdauteurs: Lipponen, Anssi, Natunen, Teemu, Hujo, Mika, Ciszek, Robert, Hämäläinen, Elina, Tohka, Jussi, Hiltunen, Mikko, Paananen, Jussi, Poulsen, David, Kansanen, Emilia, Ekolle Ndode-Ekane, Xavier, Levonen, Anna-Liisa, Pitkänen, Asla
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6861918/
https://ncbi.nlm.nih.gov/pubmed/31671916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20215395
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