In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury—Lessons Learned

We developed a pipeline for the discovery of transcriptomics-derived disease-modifying therapies and used it to validate treatments in vitro and in vivo that could be repurposed for TBI treatment. Desmethylclomipramine, ionomycin, sirolimus and trimipramine, identified by in silico LINCS analysis as...

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Библиографические подробности
Опубликовано в: :Int J Mol Sci
Главные авторы: Lipponen, Anssi, Natunen, Teemu, Hujo, Mika, Ciszek, Robert, Hämäläinen, Elina, Tohka, Jussi, Hiltunen, Mikko, Paananen, Jussi, Poulsen, David, Kansanen, Emilia, Ekolle Ndode-Ekane, Xavier, Levonen, Anna-Liisa, Pitkänen, Asla
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6861918/
https://ncbi.nlm.nih.gov/pubmed/31671916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20215395
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