In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury—Lessons Learned

We developed a pipeline for the discovery of transcriptomics-derived disease-modifying therapies and used it to validate treatments in vitro and in vivo that could be repurposed for TBI treatment. Desmethylclomipramine, ionomycin, sirolimus and trimipramine, identified by in silico LINCS analysis as...

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Xehetasun bibliografikoak
Argitaratua izan da:Int J Mol Sci
Egile Nagusiak: Lipponen, Anssi, Natunen, Teemu, Hujo, Mika, Ciszek, Robert, Hämäläinen, Elina, Tohka, Jussi, Hiltunen, Mikko, Paananen, Jussi, Poulsen, David, Kansanen, Emilia, Ekolle Ndode-Ekane, Xavier, Levonen, Anna-Liisa, Pitkänen, Asla
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: MDPI 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6861918/
https://ncbi.nlm.nih.gov/pubmed/31671916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20215395
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