Proinsulin peptide promotes autoimmune diabetes in a novel HLA-DR3-DQ2-transgenic murine model of spontaneous disease

AIMS/HYPOTHESIS: The molecular basis for the pathological impact of specific HLA molecules on autoimmune diseases such as type 1 diabetes remains unclear. Recent natural history studies in children have indicated a link between specific HLA genotypes and the first antigenic target against which immu...

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Publicado en:Diabetologia
Autores principales: Verhagen, Johan, Yusuf, Norkhairin, Smith, Emma L., Whettlock, Emily M., Naran, Kerina, Arif, Sefina, Peakman, Mark
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer Berlin Heidelberg 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6861537/
https://ncbi.nlm.nih.gov/pubmed/31612266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-019-04994-8
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