Autoimmune cardiomyopathy and heart block develop spontaneously in HLA-DQ8 transgenic IAβ knockout NOD mice

A line of nonobese diabetic (NOD) mice expressing the human diabetes-associated HLA-DQ8 transgene in the absence of mouse IA(β) failed to show spontaneous insulitis or diabetes, but rather developed dilated cardiomyopathy, leading to early death from heart failure. Pathology in these animals results...

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Detalhes bibliográficos
Main Authors: Elliott, John F., Liu, Junliang, Yuan, Zuan-Ning, Bautista-Lopez, Norma, Wallbank, Sarah L., Suzuki, Kunimasa, Rayner, David, Nation, Patrick, Robertson, Murray A., Liu, Gang, Kavanagh, Katherine M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC263834/
https://ncbi.nlm.nih.gov/pubmed/14570980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2235552100
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