Induced pluripotent stem cell macrophages present antigen to proinsulin-specific T cell receptors from donor-matched islet-infiltrating T cells in type 1 diabetes

AIMS/HYPOTHESIS: Type 1 diabetes is an autoimmune disorder characterised by loss of insulin-producing beta cells of the pancreas. Progress in understanding the cellular and molecular mechanisms underlying the human disease has been hampered by a dearth of appropriate human experimental models. We pr...

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Publicado en:Diabetologia
Autores principales: Joshi, Kriti, Elso, Colleen, Motazedian, Ali, Labonne, Tanya, Schiesser, Jacqueline V., Cameron, Fergus, Mannering, Stuart I., Elefanty, Andrew G., Stanley, Edouard G.
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer Berlin Heidelberg 2019
Materias:
Short Communication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6861360/
https://ncbi.nlm.nih.gov/pubmed/31511930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-019-04988-6
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