Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions

The over-expression and aggregation of α-synuclein (αSyn) are linked to the onset and pathology of Parkinson’s disease. Native monomeric αSyn exists in an intrinsically disordered ensemble of interconverting conformations, which has made its therapeutic targeting by small molecules highly challengin...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Tóth, Gergely, Neumann, Thomas, Berthet, Amandine, Masliah, Eliezer, Spencer, Brian, Tao, Jiahui, Jobling, Michael F., Gardai, Shyra J., Bertoncini, Carlos W., Cremades, Nunilo, Bova, Michael, Ballaron, Stephen, Chen, Xiao-Hua, Mao, Wenxian, Nguyen, Phuong, Tabios, Mariano C., Tambe, Mitali A., Rochet, Jean-Christophe, Junker, Hans-Dieter, Schwizer, Daniel, Sekul, Renate, Ott, Inge, Anderson, John P., Szoke, Balazs, Hoffman, Wherly, Christodoulou, John, Yednock, Ted, Agard, David A., Schenk, Dale, McConlogue, Lisa
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6861283/
https://ncbi.nlm.nih.gov/pubmed/31740740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52598-4
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