Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions

The over-expression and aggregation of α-synuclein (αSyn) are linked to the onset and pathology of Parkinson’s disease. Native monomeric αSyn exists in an intrinsically disordered ensemble of interconverting conformations, which has made its therapeutic targeting by small molecules highly challengin...

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Foilsithe in:Sci Rep
Main Authors: Tóth, Gergely, Neumann, Thomas, Berthet, Amandine, Masliah, Eliezer, Spencer, Brian, Tao, Jiahui, Jobling, Michael F., Gardai, Shyra J., Bertoncini, Carlos W., Cremades, Nunilo, Bova, Michael, Ballaron, Stephen, Chen, Xiao-Hua, Mao, Wenxian, Nguyen, Phuong, Tabios, Mariano C., Tambe, Mitali A., Rochet, Jean-Christophe, Junker, Hans-Dieter, Schwizer, Daniel, Sekul, Renate, Ott, Inge, Anderson, John P., Szoke, Balazs, Hoffman, Wherly, Christodoulou, John, Yednock, Ted, Agard, David A., Schenk, Dale, McConlogue, Lisa
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2019
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6861283/
https://ncbi.nlm.nih.gov/pubmed/31740740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52598-4
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