Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome

Hutchinson–Gilford progeria syndrome (HGPS) is a genetic disorder characterized by premature aging features. Cells from HGPS patients express progerin, a truncated form of Lamin A, which perturbs cellular homeostasis leading to nuclear shape alterations, genome instability, heterochromatin loss, tel...

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Publicat a:Nat Commun
Autors principals: Aguado, Julio, Sola-Carvajal, Agustin, Cancila, Valeria, Revêchon, Gwladys, Ong, Peh Fern, Jones-Weinert, Corey Winston, Wallén Arzt, Emelie, Lattanzi, Giovanna, Dreesen, Oliver, Tripodo, Claudio, Rossiello, Francesca, Eriksson, Maria, d’Adda di Fagagna, Fabrizio
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6861280/
https://ncbi.nlm.nih.gov/pubmed/31740672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13018-3
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