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Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone
Podophyllotoxin is the natural product precursor of the chemotherapeutic etoposide, yet only part of its biosynthetic pathway is known. We used transcriptome mining in Podophyllum hexandrum (mayapple) to identify biosynthetic genes in the podophyllotoxin pathway. We selected 29 candidate genes to co...
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| Publicado no: | Science |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6861171/ https://ncbi.nlm.nih.gov/pubmed/26359402 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aac7202 |
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