Computational Insight Into the Small Molecule Intervening PD-L1 Dimerization and the Potential Structure-Activity Relationship

Recently, small-molecule compounds have been reported to block the PD-1/PD-L1 interaction by inducing the dimerization of PD-L1. All these inhibitors had a common scaffold and interacted with the cavity formed by two PD-L1 monomers. This special interactive mode provided clues for the structure-base...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Front Chem
Hauptverfasser: Shi, Danfeng, An, Xiaoli, Bai, Qifeng, Bing, Zhitong, Zhou, Shuangyan, Liu, Huanxiang, Yao, Xiaojun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6861162/
https://ncbi.nlm.nih.gov/pubmed/31781546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2019.00764
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