Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas

RNA polymerase III (Pol-III) transcribes tRNAs and other small RNAs essential for protein synthesis and cell growth. Pol-III is deregulated during carcinogenesis; however, its role in vivo has not been studied. To address this issue, we manipulated levels of Brf1, a Pol-III transcription factor that...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Liko, Dritan, Mitchell, Louise, Campbell, Kirsteen J., Ridgway, Rachel A., Jones, Carolyn, Dudek, Kate, King, Ayala, Bryson, Sheila, Stevenson, David, Blyth, Karen, Strathdee, Douglas, Morton, Jennifer P., Bird, Thomas G., Knight, John R. P., Willis, Anne E., Sansom, Owen J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6861133/
https://ncbi.nlm.nih.gov/pubmed/30858608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0316-7
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