The lipid droplet-associated protein ABHD5 protects the heart through proteolysis of HDAC4

Catecholamines stimulate the first step of lipolysis by PKA-dependent release of the lipid droplet-associated protein ABHD5 from perilipin to co-activate the lipase ATGL. Here, we unmask a yet unrecognized proteolytic and cardioprotective function of ABHD5. ABHD5 acts in vivo and in vitro as a serin...

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Udgivet i:Nat Metab
Main Authors: Jebessa, Zegeye H., Shanmukha Kumar, D., Dewenter, Matthias, Lehmann, Lorenz H., Xu, Chang, Schreiter, Friederike, Siede, Dominik, Gong, Xue-Min, Worst, Barbara C, Federico, Guiseppina, Sauer, Sven W., Fischer, Tamas, Wechselberger, Lisa, Müller, Oliver J., Sossalla, Samuel, Dieterich, Christoph, Most, Patrick, Gröne, Herrmann-Josef, Moro, Cedric, Oberer, Monika, Haemmerle, Guenter, Katus, Hugo A., Tyedmers, Jens, Backs, Johannes
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6861130/
https://ncbi.nlm.nih.gov/pubmed/31742248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-019-0138-4
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