Selective repression of MEF2 activity by PKA-dependent proteolysis of HDAC4

Histone deacetylase 4 (HDAC4) regulates numerous gene expression programs through its signal-dependent repression of myocyte enhancer factor 2 (MEF2) and serum response factor (SRF) transcription factors. In cardiomyocytes, calcium/calmodulin-dependent protein kinase II (CaMKII) signaling promotes h...

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Autores principales: Backs, Johannes, Worst, Barbara C., Lehmann, Lorenz H., Patrick, David M., Jebessa, Zegeye, Kreusser, Michael M., Sun, Qiang, Chen, Lan, Heft, Claudia, Katus, Hugo A., Olson, Eric N.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2011
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3206346/
https://ncbi.nlm.nih.gov/pubmed/22042619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201105063
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