Mitochondrial clearance and maturation of autophagosomes are compromised in LRRK2 G2019S familial Parkinson’s disease patient fibroblasts

This study utilized human fibroblasts as a preclinical discovery and diagnostic platform for identification of cell biological signatures specific for the LRRK2 G2019S mutation producing Parkinson’s disease (PD). Using live cell imaging with a pH-sensitive Rosella biosensor probe reflecting lysosoma...

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Publicado en:Hum Mol Genet
Autores principales: Korecka, Joanna A, Thomas, Ria, Christensen, Dan P, Hinrich, Anthony J, Ferrari, Eliza J, Levy, Simon A, Hastings, Michelle L, Hallett, Penelope J, Isacson, Ole
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2019
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General Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6859523/
https://ncbi.nlm.nih.gov/pubmed/31261377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz126
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